UC Irvine

McWhorter F.Y., Smith T.D., Luu T.U., Rahim M.K., Haun J.B., Liu W.F. (2016) Macrophage secretion heterogeneity in engineered microenvironments revealed using a microwell platform. Integrative Biology. Advance article. doi:10.1039/C6IB00053C

Alfonso GarcĂ­a A., Smith T.D., Datta R., Luu T.U., Gratton E., Potma E.O., Liu W.F. (2016) Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy. Journal of Biomedical Optics. 21(4):46007. doi:10.1117/1.JBO.21.4.046005

Wang T., Luu T.U., Chen A., Khine M., Liu W.F. (2016) Topographical modulation of macrophage phenotype by shrink film multi-scale wrinkles. Biomaterials Science. 4:948-52. doi:10.1039/C6BM00224B

Luu T.U., Gott S.C., Woo B.W.K., Rao M.P., Liu W.F. (2015) Micro and nano-patterned topographical cues for regulating macrophage cell shape and phenotype. ACS Applied Materials and Interfaces. 7(51):28665-72. doi:10.1021/acsami.5b10589

Kim Y.K., Chen E.Y., Liu W.F. (2015) Biomolecular strategies to modulate the macrophage response to implanted materials. J. Mater. Chem. B. doi:10.1039/c5tb01605c

McWhorter F.Y., Davis C.T., Liu W.F. (2015) Physical and mechanical regulation of macrophage phenotype and function. Cell Mol. Life Sci. 72(7):1303-16. doi:10.1007/s00018-014-1796-8

Harker KS, Jivan E, McWhorter FY, Liu WF, Lodoen MB.  (2014) Shear Forces Enhance Toxoplasma gondii Tachyzoite Motility on Vascular Endothelium.  MBio. 5(2): 01111-13. doi:10.1128/mBio.01111-13

Kim YK, Que R, Wang SW, Liu WF.  (2014) Modification of Biomaterials with a Self-Protein Inhibits the Macrophage Response.  Adv. Healthcare Mat.  Feb 20.  doi:10.1002/adhm.201300532

Ueno N, Harker KS, Clarke EV, McWhorter FY, Liu WF, Tenner AJ, Lodoen MB. (2013) Real-time imaging of infected human monocytes under fluidic shear stress reveals rapid translocation of intracellular parasites across endothelial barriers. Cell Microbiol. Dec 4. doi:10.1111/cmi.12239

McWhorter FY*, Wang T*, Nguyen P, Chung T, Liu WF. (2013) Modulation of macrophage phenotype by cell shape. Proc Nat Acad Sci USA. doi:10.1073/pnas.1308887110. Download

Harker K.S., Ueno N., Wang T., Bonhomme C., Liu W., Lodoen M.B. (2013) Toxoplasma gondii modulates the dynamics of human monocyte adhesion to vascular endothelium under fluidic shear stress. J Leukoc Biol. 93(5)789-800.

Dheda S.S., Kim Y.K., Melnyk C., Liu W., Mohamed F.A. (2013) Corrosion and in vitro biocompatibility properties of cryomilled-spark plasma sintered commercially pure titanium. J Mater Sci Mater Med. 24(5):1239-49.

Alavi S.H., Liu W.F., Kheradvar A. (2013) Inflammatory Response Assessment of a Hybrid Tissue-Engineered Heart Valve Leaflet. Ann Biomed Eng. 42(2):316-26.

Leight, J.L., Liu, W.F., Chaturvedi R.R., Chen S., Yang M.T., Raghavan S., Chen C.S. (2012) Manipulation of 3D Cluster Size and Geometry by Release from 2D Micropatterns. Cell and Mol Bioengineering. 5(3):299-306.

Liu WF. (2012) Mechanical regulation of cellular phenotype: implications for vascular tissue regeneration. Cardiovasc Res. 95(2)251-22.

Prior to UCI

Ma M, Liu WF, Chin J, Langer R, Anderson DG. (2011) Novel cationic polymer coatings to regulate the foreign body response. Adv. Mater. 23(24):H189-94.

Liu WF, Ma M, Langer R, Anderson DG. (2011) Real-time in vivo detection of biomaterial-induced reactive oxygen species, Biomaterials, 32(7) 1796-801.

Desai R, Gao L, Raghavan S, WF Liu WF, Chen CS. (2009) Cell polarity triggered by cell-cell adhesion via E-cadherin. J. Cell Sci., 122(7) 905-11.

Gray DS, Liu WF, Shen CJ, Bhadriraju K, Nelson CM, Chen CS. (2008) Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Exp. Cell Res. 314(15):2846-54.

Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK. (2008) Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. J. Cell Sci. 121(Pt2):226-33.

Liu WF, Chen CS. (2007) Cellular and multicellular form and function. Adv. Drug Deliv. Rev. 59(13):1319- 28.

Liu WF, Nelson CM, Tan JL, Chen CS. (2007) Cadherins, RhoA and Rac1 are differentially required for stretch-mediated proliferation of endothelial versus smooth muscle cells. Circulation Research. 101(5):e44-52.

Pirone DM, Liu WF, Alom Ruiz S, Raghavan S, Lemmon CA, Romer L, Chen CS. (2006) An inhibitory role for FAK in regulating cell proliferation: a link between limited adhesion and RhoA-ROCK signaling. J. Cell Biology 174(2):277-88.

Liu WF, Nelson CM, Pirone DM, Chen CS. (2006) E-cadherin engagement stimulates proliferation via Rac1. J. Cell Biology 173(3):431-41.

Liu WF and Chen CS. (2005) Engineering cell function through cell-biomaterial interactions. Materials Today 12(8):28-3.

Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, Spector AA, Chen CS. (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc. Natl. Acad. Sci. USA 102(33):11594-9.

Tan JL, Liu W, Nelson CM, Raghavan S, Chen CS. (2004) Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Eng. 10(5-6):865-72.

Book chapters

Liu WF, EE Hui, SN Bhatia, SC Chen. (2008) “Engineering cellular microenvironments”. Principles of Regenerative Medicine. (ed. A. Atala, R. Lanza, J. Thomson, R. Nerem). Academic Press. 536-553.

Nelson CM, Liu WF, and Chen CS. (2007) “Manipulation of cell-cell adhesion using bowtie-shaped microwells”. In Methods in Molecular Biology: Adhesion Protein Protocols, Second Edition. (ed. A.S. Coutts). Humana Press. 270: 1-9.

Bhadriraju K, Liu WF, Gray DS, and Chen CS. (2006) “Engineering Cell Adhesion”. BioMEMS and Biomedical Nanotechnology III. Therapeutic Micro/Nanotechnology. (ed. M. Ferrari, T. Desai, and S. Bhatia ). Springer. 315-330.


Liu W.F., Kim Y.K.. Immunomodulatory materials for implantable medical devices. U.S. Provisional Application, Filing Date: September, 2012.

Chen A, Wang T, Liu WF, Khine M. Preparation and use of nanowrinkles. U.S. Provisional Application No 61/440,356. Filing Date: February 7, 2011.

Ma M, Liu WF, Langer R, Anderson DG. Poly (beta-amino alcohols), their preparation and uses thereof. U.S. Provisional Application No 61/377,348. Filing Date: August 26, 2010.